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Red Grape Juice Consumption and Heart Disease

Red Grape Juice Consumption and Heart Disease

Red grape juice is a good source of polyphenols.  Polyphenols which were once known as ‘vitamin P’ are chemicals found in plants which may have antioxidant activity.  Further, these chemical substances found in plants may reduce the risk of cardiovascular disease and cancer.

A recent study demonstrated that consumption of red grape juice concentrate reduces cholesterol levels as well as Apolipoprotein B levels in hemodialysis patients.  High levels of Apolipoprotein B are related to heart disease.

Does Red Grape Juice Lower the Risk of Cardiovascular Disease?

Study Background:

“Atherosclerotic cardiovascular disease is the most common cause of death among hemodialysis patients; it has been attributed to increased oxidative stress, dyslipidemia, malnutrition, and chronic inflammation. Activation of neutrophils is a well-recognized feature in dialysis patients, and superoxide-anion production by neutrophil NADPH oxidase may contribute significantly to oxidative stress.”

Study Results:

 RGJ consumption but not vitamin E consumption reduced plasma concentrations of total cholesterol and apolipoprotein B and increased those of HDL cholesterol. Both RGJ and vitamin E reduced plasma concentrations of oxidized LDL and ex vivo neutrophil NADPH oxidase activity. These effects were intensified when the supplements were used in combination; in that case, reductions in the inflammatory biomarkers intercellular adhesion molecule 1 and monocyte chemoattractant protein 1 also were observed.

Study Conclusions:

“Regular ingestion of concentrated RGJ by hemodialysis patients reduces neutrophil NADPH-oxidase activity and plasma concentrations of oxidized LDL and inflammatory biomarkers to a greater extent than does that of vitamin E. This effect of RGJ consumption may favor a reduction in cardiovascular risk.”


  • Red grape juice is an important source of antioxidants–known as polyphenols or vitamin P.
  • Red grape juice consumption may lower cholesterol, apolipoprotein E levels and may, therefore, lower your risk of cardiovascular disease.


  1. Castilla P, Dávalos A, Teruel JL, Cerrato F, Fernández-Lucas M, Merino JL, Sánchez-Martín CC, Ortuño J, Lasunción MA.  Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients.  Am J Clin Nutr. 2008 Apr;87(4):1053-61.


  • Jarret Morrow

    The results of previous study by the Castilla et al (2006) also supports these results in both hemodialysis patients as well as healthy controls: "RESULTS: The maximum plasma concentration of quercetin was achieved 3 h after RGJ ingestion, which indicates that supplement-derived polyphenols are rapidly absorbed. In both healthy subjects and hemodialysis patients, RGJ consumption increased the antioxidant capacity of plasma without affecting concentrations of uric acid or ascorbic acid; reduced the concentration of oxidized LDL; and increased the concentration of cholesterol-standardized alpha-tocopherol. RGJ supplementation also caused a significant decrease in LDL-cholesterol and apolipoprotein B-100 concentrations, while increasing the concentrations of HDL cholesterol and apolipoprotein A-I. In a further study in hemodialysis patients, RGJ supplementation for 3 wk significantly reduced plasma monocyte chemoattractant protein 1, an inflammatory biomarker associated with cardiovascular disease risk." Castilla P, Echarri R, Dávalos A, Cerrato F, Ortega H, Teruel JL, Lucas MF, Gómez-Coronado D, Ortuño J, Lasunción MA. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin Nutr. 2006 Jul;84(1):252-62.

  • Lora Linen

    What a fantastic publish about Red Grape Juice, wow.

  • Shakita Mansell

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  • Susan P

    Thank you for all the helpful information. i cant wait to share this info with my family because heart disease and high cholesterol are very common in my family. Im planning on drinking a lot of red grape juice. I want to try to prevent having the high cholesterol and cardiovascular disease like the rest of my family.

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